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KMID : 1007520030120060659
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Food Science and Biotechnology
2003 Volume.12 No. 6 p.659 ~ p.663
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Protective Effect of Ginseng against Endocrine Disrupting Toxicity Induced by Butyl p-Hydroxybenzoic Acid
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Ahn, Ji-Yun
Ha, Tae-Youl/Kim, Sung-Ran/Kang, Kyung-Sun/Han, Chan-Kyu
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Abstract
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Butyl p-hydroxybenzoic acid (butyl paraben, BP) is a homologous series of parabens and is used as a preservative in food and cosmetic products. BP has been shown to display endocrine disrupting toxicity in both in vitro and in vivo analyses. In this study, the effect of ginseng treatment on the toxicity of BP was investigated by examining whether or not ginseng exhibited oestorogenicity. Cinseng itself did not exert an estrogenic effect in the yeast estrogen receptor (YER) assay. In E-screen, 70% methanol extract of 6-year-old red ginseng (6R) increased MCF-7 proliferation. In contrast, 70% methanol extract of 40year-old red ginseng (4R) slightly decreased MCF-7 proliferation. The ginseng extracts considerably inhibited activation of β-galactosidase by 100 ㎛ BP, and red ginseng and methanol extraction were more conducive to detoxifying the effect of BP than white ginseng and water extraction. For E-screen, ginseng extracts successfully suppressed BP-induced MCG-7 proliferation. The 6R inhibited MCF-7 proliferation induced by 10㎛ of BP, dose-dependently, in both water and 70% methanol extract. The results of this study suggested ginseng to be effective for reducing BP toxicity in vitro.
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KEYWORD
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